In a very latest review, we noted the identification and also the characterization of a new atypical opioid receptor with distinctive detrimental regulatory properties to opioid peptides.1 Our success showed that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can be a wide-spectrum scavenger for opio